Regulation of maintenance of sister chromatid cohesion

Across TCGA patient cohorts, RNA activity of the Regulation of maintenance of sister chromatid cohesion pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TIMELESS_S1173, TOP2A, and TOP2A_S1106, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of maintenance of sister chromatid cohesion activity versus TIMELESS_S1173 in UCEC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIMELESS_S1173 →	+0.647	+0.067	<.001	<.001	3	9
UCEC	TOP2A →	+1.093	+0.094	<.001	<.001	3	9
LUAD	TOP2A_S1106 →	+1.269	+0.091	<.001	<.001	3	9
PDAC	PBK →	+0.665	+0.055	<.001	<.001	3	9
GBM	PRIM2 →	+0.449	+0.069	.001	<.001	3	9
LUAD	RFC1_T506 →	+1.138	+0.097	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034091 vs TIMELESS_S1173 — UCEC

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