Maintenance of sister chromatid cohesion

Across TCGA patient cohorts, RNA activity of the Maintenance of sister chromatid cohesion pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC2, SMC4, and TPX2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of sister chromatid cohesion activity versus SMC2 in UCEC (Pearson r = 0.59).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SMC2 →	+0.744	+0.113	<.001	<.001	3	9
LUAD	SMC4 →	+0.659	+0.099	<.001	<.001	3	9
LUAD	TPX2 →	+0.941	+0.098	<.001	<.001	3	9
GBM	PRIM2 →	+0.442	+0.050	.001	.003	3	9
LUAD	RFC1_T506 →	+1.284	+0.100	<.001	<.001	3	8
LUAD	RIF1_S782 →	+0.690	+0.084	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034086 vs SMC2 — UCEC

Explore this scatter interactively →