CENP-A containing chromatin assembly

Across TCGA cell cohorts, RNA activity of the CENP-A containing chromatin assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPW, CENPA, and OIP5, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CENPW grouped by CENP-A containing chromatin assembly-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CENPW →	-0.579	-1.559	<.001	<.001	3	13
OESOPHAGUS	CENPA →	-0.319	-0.449	.001	.007	2	10
LUNG_NSCLC_LUSC	OIP5 →	-0.433	-0.333	.005	<.001	3	9
BREAST	ITGB3BP →	-0.164	-0.228	.005	.003	3	7
URINARY_TRACT	CASR →	+0.377	+2.215	.003	<.001	3	5
OESOPHAGUS	TOB1 →	+0.164	+0.411	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CENPW by CENP-A containing chromatin assembly activity — PANCREAS

Explore this box plot interactively →