Endosomal vesicle fusion

Across TCGA patient cohorts, RNA activity of the Endosomal vesicle fusion pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HMG20A_S105, DAB2, and FZD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endosomal vesicle fusion activity versus HMG20A_S105 in BRCA (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HMG20A_S105 →	-0.444	-0.046	.007	<.001	3	6
BRCA	DAB2 →	+0.426	+0.042	<.001	<.001	3	6
OV	FZD1 →	+0.749	+0.043	.004	.001	3	6
COAD	TOMM70 →	-0.344	-0.040	<.001	<.001	3	5
CCRCC	VWF →	+0.464	+0.036	.002	.008	3	5
BRCA	CKAP4 →	+0.445	+0.036	.008	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034058 vs HMG20A_S105 — BRCA

Explore this scatter interactively →