Nucleoside bisphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Nucleoside bisphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FXN, MRPS11, and MTCL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FXN grouped by Nucleoside bisphosphate metabolic process-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	FXN →	+0.998	+1.345	.003	.002	3	5
LUNG_NSCLC_LUSC	MRPS11 →	+0.573	+1.219	.004	.006	3	4
BLOOD_Leukemia	MTCL1 →	+1.829	+1.066	.003	.006	3	4
BLOOD_Leukemia	GBP1 →	+2.172	+1.059	.002	.003	3	3
SOFT_TISSUE	UPF3B →	-0.708	-1.197	.003	.009	3	3
LUNG_NSCLC_LUSC	TAGLN →	-3.558	-1.105	.006	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FXN by Nucleoside bisphosphate metabolic process activity — OESOPHAGUS

Explore this box plot interactively →