Nucleoside bisphosphate metabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Nucleoside bisphosphate metabolic process pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 124 member genes.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher Nucleoside bisphosphate metabolic process pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LIHC and LUSC, show the opposite pattern, with higher activity associated with better survival.

LIHC, UCEC, and LUSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	All	0.792	0.592	<.001	39	view →
UCEC	OS	Tertile	All	0.812	0.894	.019	22	view →
LUSC	OS	Tertile	II,III,IV	0.848	0.671	.015	19	view →
CHOL	DFS	Quartile	III,IV	0.031	0.618	.017	16	view →
LUAD	DFS	Median	II,III,IV	0.627	0.786	.014	15	view →
CESC	DFS	Tertile	IV	0.286	0.647	.025	14	view →
READ	OS	Tertile	IV	0.539	1.000	.007	14	view →
KICH	DFS	Median	All	1.000	0.735	.026	10	view →
UVM	OS	Quartile	III,IV	0.320	1.000	.003	10	view →
COAD	OS	Median	IV	0.637	0.411	.015	10	view →
GBM	OS	Tertile	All	0.252	0.445	.005	6	view →
BLCA	OS	Quartile	All	1.000	0.572	.007	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0033865–LIHC (OS)

Open the LIHC breakdown →