Osteoblast proliferation

Across TCGA cell cohorts, RNA activity of the Osteoblast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYBRD1, NTN4, and DUSP14, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYBRD1 grouped by Osteoblast proliferation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CYBRD1 →	+3.486	+1.373	.003	.001	3	3
STOMACH	NTN4 →	+3.120	+1.229	<.001	.001	3	3
BLOOD_Myeloma	DUSP14 →	-2.260	-1.582	.006	.005	2	4
LUNG_SCLC	ZFY →	+1.773	+1.341	.005	.001	3	3
BLOOD_Leukemia	RAP1A →	+0.741	+1.718	<.001	<.001	3	3
BLOOD_Leukemia	TPRA1 →	+0.721	+1.259	.007	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYBRD1 by Osteoblast proliferation activity — STOMACH

Explore this box plot interactively →