Positive regulation of cell adhesion mediated by integrin

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell adhesion mediated by integrin pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TXN2, PHC1, and FER, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TXN2 grouped by Positive regulation of cell adhesion mediated by integrin-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TXN2 →	+0.609	+1.018	.003	.001	3	4
OVARY	PHC1 →	-1.007	-0.997	<.001	<.001	3	4
OESOPHAGUS	FER →	-0.957	-1.142	<.001	<.001	3	4
SOFT_TISSUE	DCAKD →	-0.720	-1.032	.001	.003	3	4
BLOOD_Leukemia	PER1 →	-0.739	-1.290	.005	<.001	3	4
OVARY	MYLK2 →	-0.454	-0.948	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TXN2 by Positive regulation of cell adhesion mediated by integrin activity — OVARY

Explore this box plot interactively →