Positive regulation of cell adhesion mediated by integrin

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of cell adhesion mediated by integrin pathway differs between tumor and matched normal tissue in 10 of the 18 cancer types tested.

The strongest signal is observed in stomach adenocarcinoma (STAD), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KICH and THCA, show the opposite pattern, with lower activity in tumor tissue.

STAD, KIRC, and LUAD show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
STAD	All	II,III,IV	+0.078	<.001	8	view →
KIRC	Male	All	+0.051	<.001	7	view →
LUAD	Female	All	+0.059	<.001	6	view →
KICH	All	All	−0.048	<.001	6	view →
HNSC	All	All	+0.030	.001	6	view →
THCA	Female	All	−0.040	<.001	5	view →
BRCA	Female	II,III,IV	−0.018	.010	4	view →
CHOL	All	All	+0.073	<.001	2	view →
LIHC	Male	All	−0.027	.013	2	view →
PRAD	All	All	−0.017	.042	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 10 strongest of 10 lineages.

GO:0033630–STAD

Open the STAD breakdown →