Positive regulation of cell adhesion mediated by integrin

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell adhesion mediated by integrin pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PODXL, CAV2, and GBP3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell adhesion mediated by integrin activity versus PODXL in CNS (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PODXL →	+2.663	+1.064	.002	.001	3	6
STOMACH	CAV2 →	+3.235	+0.913	.003	.004	3	4
STOMACH	GBP3 →	+2.228	+0.997	.001	.001	3	4
STOMACH	C4BPB →	+3.365	+1.012	<.001	.001	3	4
STOMACH	C19orf33 →	+5.066	+1.238	.007	.003	3	4
STOMACH	ITGA6 →	+2.676	+1.572	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033630 vs PODXL — CNS

Explore this scatter interactively →