Negative regulation of cell adhesion mediated by integrin

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell adhesion mediated by integrin pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MOB3C, APOL6, and UTP18, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell adhesion mediated by integrin activity versus MOB3C in BLOOD_Lymphoma (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MOB3C →	-1.452	-0.785	<.001	.003	3	4
BLOOD_Lymphoma	APOL6 →	-1.527	-0.554	<.001	.004	3	4
URINARY_TRACT	UTP18 →	+0.620	+0.441	.007	.001	2	5
URINARY_TRACT	KLHL31 →	-0.385	-0.412	<.001	.001	3	4
BONE	SCLT1 →	+0.827	+0.315	.005	.001	3	4
OESOPHAGUS	NAGLU →	-1.012	-1.424	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033629 vs MOB3C — BLOOD_Lymphoma

Explore this scatter interactively →