Membrane protein proteolysis

Across TCGA patient cohorts, RNA activity of the Membrane protein proteolysis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DPYD, PYCARD, and SERPINB9, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane protein proteolysis activity versus DPYD in LSCC (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DPYD →	+0.487	+0.043	<.001	<.001	3	7
GBM	PYCARD →	+0.581	+0.070	<.001	<.001	3	7
BRCA	SERPINB9 →	+0.412	+0.024	.002	.003	3	6
LSCC	COTL1 →	+0.432	+0.043	<.001	<.001	3	6
GBM	SKAP2 →	+0.506	+0.052	<.001	<.001	3	6
GBM	CASP4 →	+0.442	+0.039	.003	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033619 vs DPYD — LSCC

Explore this scatter interactively →