Membrane protein proteolysis

Across TCGA cell cohorts, RNA activity of the Membrane protein proteolysis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPPL2A, SEL1L, and SERINC3, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane protein proteolysis activity versus SPPL2A in STOMACH (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SPPL2A →	+1.055	+0.132	<.001	<.001	3	17
BLOOD_Lymphoma	SEL1L →	+1.401	+0.094	<.001	<.001	3	17
STOMACH	SERINC3 →	+1.004	+0.099	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	NUCB1 →	+1.274	+0.153	<.001	<.001	3	16
BONE	LAMP2 →	+1.592	+0.119	<.001	.002	3	16
OESOPHAGUS	ERAP1 →	+1.756	+0.154	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033619 vs SPPL2A — STOMACH

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