Membrane protein proteolysis

Across TCGA cell cohorts, RNA activity of the Membrane protein proteolysis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DAG1, THBS1, and NDUFB9, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane protein proteolysis activity versus DAG1 in LARGE_INTESTINE (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DAG1 →	+1.303	+0.305	.001	<.001	3	7
LARGE_INTESTINE	THBS1 →	+1.841	+0.160	<.001	.001	3	5
CNS	NDUFB9 →	-0.777	-0.212	<.001	.001	3	5
LUNG_SCLC	LYPLA1 →	-1.210	-0.396	<.001	<.001	3	5
LUNG_NSCLC_LUAD	DPH5 →	-0.807	-0.203	<.001	<.001	3	5
LIVER	C5orf46 →	+3.885	+0.273	.004	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033619 vs DAG1 — LARGE_INTESTINE

Explore this scatter interactively →