Mitochondrial cytochrome c oxidase assembly

Across TCGA cell cohorts, RNA activity of the Mitochondrial cytochrome c oxidase assembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLEKHG2, GRTP1, and RAB42, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLEKHG2 grouped by Mitochondrial cytochrome c oxidase assembly-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PLEKHG2 →	-1.083	-1.783	<.001	<.001	3	3
OVARY	GRTP1 →	+1.538	+1.351	<.001	<.001	3	3
OVARY	RAB42 →	-1.501	-0.993	<.001	.002	3	3
CNS	PGF →	-1.910	-1.026	.002	.001	3	3
CNS	XXYLT1 →	-0.737	-0.844	.005	.007	3	3
CNS	C12orf60 →	+0.772	+1.044	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLEKHG2 by Mitochondrial cytochrome c oxidase assembly activity — BLOOD_Lymphoma

Explore this box plot interactively →