Positive regulation of mammary gland epithelial cell proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of mammary gland epithelial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSE1L, MICU1, and CD34, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mammary gland epithelial cell proliferation activity versus CSE1L in HNSC (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CSE1L →	+0.691	+0.197	.005	<.001	3	5
CCRCC	MICU1 →	+0.304	+0.202	.006	<.001	3	4
PDAC	CD34 →	-0.328	-0.276	<.001	.008	3	4
OV	USP17L1 →	+0.041	+0.240	.006	.002	3	4
LSCC	HMGN3 →	+0.428	+0.468	<.001	.003	3	4
HNSC	WRNIP1 →	+0.959	+0.216	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033601 vs CSE1L — HNSC

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