Positive regulation of mammary gland epithelial cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of mammary gland epithelial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPHA4, SAP130, and CCDC88C, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EPHA4 grouped by Positive regulation of mammary gland epithelial cell proliferation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	EPHA4 →	+1.334	+1.485	.009	.002	3	2
SKIN	SAP130 →	+0.414	+1.675	<.001	<.001	3	2
SKIN	CCDC88C →	+1.180	+1.608	.001	<.001	3	2
SKIN	HPS3 →	+0.947	+1.408	.008	.002	2	3
STOMACH	FREM2 →	+2.740	+2.029	<.001	<.001	3	2
STOMACH	GALR2 →	+0.217	+2.029	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EPHA4 by Positive regulation of mammary gland epithelial cell proliferation activity — SKIN

Explore this box plot interactively →