Positive regulation of mammary gland epithelial cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of mammary gland epithelial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TXNRD2, ESS2, and SLC5A1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mammary gland epithelial cell proliferation activity versus TXNRD2 in LARGE_INTESTINE (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TXNRD2 →	+1.294	+0.237	.001	.007	3	2
LARGE_INTESTINE	ESS2 →	+0.701	+0.165	<.001	.001	3	1
LARGE_INTESTINE	SLC5A1 →	-2.531	-0.148	.001	.001	3	1
LARGE_INTESTINE	CRNKL1 →	-0.703	-0.221	.002	.005	3	1
LARGE_INTESTINE	EHD4 →	+0.823	+0.176	.004	<.001	3	1
LARGE_INTESTINE	USF2 →	+0.661	+0.145	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033601 vs TXNRD2 — LARGE_INTESTINE

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