Regulation of mammary gland epithelial cell proliferation

Across TCGA patient cohorts, RNA activity of the Regulation of mammary gland epithelial cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SAP30, NUF2, and ZNF687, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mammary gland epithelial cell proliferation activity versus SAP30 in LUAD (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SAP30 →	+0.399	+0.063	<.001	<.001	3	7
UCEC	NUF2 →	+0.441	+0.090	<.001	<.001	3	7
COAD	ZNF687 →	+0.307	+0.032	.006	.005	3	6
UCEC	HJURP_S412 →	+1.322	+0.074	<.001	<.001	3	6
HNSC	TIPIN →	+0.766	+0.105	<.001	<.001	3	6
LSCC	TOPBP1 →	+0.349	+0.063	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033599 vs SAP30 — LUAD

Explore this scatter interactively →