Mammary gland epithelial cell proliferation

pathway activity — cross-omics
GO:0033598Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Mammary gland epithelial cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRAPPC9, CISD2, and GOLGA3_S22, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCTRAPPC9 →-0.145-0.041<.001.00235
CCRCCCISD2 →-0.284-0.026.004.00735
LSCCGOLGA3_S22 →-0.545-0.044<.001.00335
CCRCCIL18 →-0.416-0.035<.001.00335
COADNUP133 →+0.145+0.036.001.00135
LSCCSOWAHC →+0.306+0.049.002.00135
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration