Anterior/posterior axon guidance

Across TCGA patient cohorts, RNA activity of the Anterior/posterior axon guidance pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM204, CLEC14A, and UNC5B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Anterior/posterior axon guidance activity versus TMEM204 in CCRCC (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TMEM204 →	+1.188	+0.157	.007	.006	3	5
CCRCC	CLEC14A →	+1.226	+0.179	.008	.001	3	4
BRCA	UNC5B →	+1.146	+0.144	<.001	<.001	3	4
BRCA	TSPAN9 →	+0.475	+0.089	.006	.007	3	4
BRCA	COL12A1 →	+1.528	+0.150	<.001	<.001	3	4
BRCA	LOXL1 →	+1.225	+0.170	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033564 vs TMEM204 — CCRCC

Explore this scatter interactively →