Multicellular organismal response to stress

Across TCGA cell cohorts, RNA activity of the Multicellular organismal response to stress pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AACS, SERPINE2, and PPIE, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AACS grouped by Multicellular organismal response to stress-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	AACS →	+0.652	+0.343	.004	<.001	3	4
LUNG_NSCLC_LUAD	SERPINE2 →	-2.880	-0.652	<.001	.002	3	4
UPPER_AERODIGESTIVE_TRACT	PPIE →	-0.900	-1.028	<.001	.002	3	4
LARGE_INTESTINE	BBS4 →	-0.559	-0.265	.006	.001	2	5
LARGE_INTESTINE	ZNF445 →	-0.405	-0.371	.004	.006	3	4
BREAST	ITGB1 →	-1.225	-0.668	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AACS by Multicellular organismal response to stress activity — BLOOD_Myeloma

Explore this box plot interactively →