Fatty acid beta-oxidation using acyl-CoA dehydrogenase

Across TCGA cell cohorts, RNA activity of the Fatty acid beta-oxidation using acyl-CoA dehydrogenase pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KATNAL2, PATL2, and SLC12A4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KATNAL2 grouped by Fatty acid beta-oxidation using acyl-CoA dehydrogenase-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KATNAL2 →	-1.202	-0.654	.004	.009	3	4
CNS	PATL2 →	-0.558	-1.011	<.001	<.001	3	4
SKIN	SLC12A4 →	-0.800	-0.796	.009	.008	3	4
LARGE_INTESTINE	PPFIA3 →	-0.890	-0.983	.001	.002	3	4
PANCREAS	PNPLA8 →	-0.695	-0.678	.005	.007	3	4
CNS	MINDY1 →	-0.613	-1.130	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KATNAL2 by Fatty acid beta-oxidation using acyl-CoA dehydrogenase activity — SOFT_TISSUE

Explore this box plot interactively →