Carbohydrate homeostasis

Across TCGA patient cohorts, RNA activity of the Carbohydrate homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RETREG2_T334, SEC16A_S1398, and SIK2_S576, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carbohydrate homeostasis activity versus RETREG2_T334 in COAD (Pearson r = -0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RETREG2_T334 →	-0.370	-0.313	.004	<.001	3	1
COAD	SEC16A_S1398 →	-0.603	-0.343	.002	.001	3	1
COAD	SIK2_S576 →	+0.543	+0.304	<.001	.005	3	1
COAD	SST →	-1.054	-0.287	<.001	.001	3	1
COAD	SYNPO2_S1079 →	-2.057	-0.415	<.001	.002	3	1
COAD	USP3 →	-0.401	-0.316	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033500 vs RETREG2_T334 — COAD

Explore this scatter interactively →