Carbohydrate homeostasis

Across TCGA cell cohorts, RNA activity of the Carbohydrate homeostasis pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR24, PSKH1, and MYNN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WDR24 grouped by Carbohydrate homeostasis-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	WDR24 →	-0.296	-0.048	.001	<.001	3	4
BLOOD_Myeloma	PSKH1 →	-0.202	-0.054	.005	<.001	3	4
LUNG_SCLC	MYNN →	+0.147	+0.057	.002	<.001	3	4
BLOOD_Leukemia	RAB22A →	-0.283	-0.050	.002	.003	2	5
OVARY	CIB1 →	+0.210	+0.072	<.001	<.001	3	4
OESOPHAGUS	LGR5 →	+0.145	+0.064	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WDR24 by Carbohydrate homeostasis activity — BLOOD_Myeloma

Explore this box plot interactively →