Response to vitamin D

Across TCGA cell cohorts, RNA activity of the Response to vitamin D pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC5A6, MROH1, and TJP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC5A6 grouped by Response to vitamin D-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SLC5A6 →	+1.180	+1.290	<.001	.001	3	4
LIVER	MROH1 →	-0.875	-1.339	.002	<.001	3	4
KIDNEY	TJP1 →	+0.793	+0.866	.005	.009	3	3
BLOOD_Myeloma	SLC39A14 →	+1.662	+1.582	.003	.002	3	3
KIDNEY	LEPROTL1 →	+0.744	+1.065	.005	.007	3	3
CNS	MYBBP1A →	+0.539	+0.976	.002	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC5A6 by Response to vitamin D activity — LIVER

Explore this box plot interactively →