Response to vitamin D

Across TCGA cell cohorts, RNA activity of the Response to vitamin D pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPCS3, KCNMB4, and GATA2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to vitamin D activity versus SPCS3 in OESOPHAGUS (Pearson r = -0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SPCS3 →	-0.731	-1.544	.009	<.001	3	4
URINARY_TRACT	KCNMB4 →	-2.000	-1.891	.002	<.001	3	4
STOMACH	GATA2 →	-2.714	-1.672	<.001	.001	3	4
BLOOD_Leukemia	HM13 →	-0.525	-0.767	<.001	.006	3	3
BLOOD_Leukemia	METTL5 →	-0.503	-0.890	.003	.006	3	3
STOMACH	FZD7 →	-1.987	-1.345	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033280 vs SPCS3 — OESOPHAGUS

Explore this scatter interactively →