Response to vitamin

Across TCGA patient cohorts, RNA activity of the Response to vitamin pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DPYD, C1S, and C1R, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to vitamin activity versus DPYD in GBM (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DPYD →	+0.832	+0.034	<.001	<.001	3	9
GBM	C1S →	+0.591	+0.047	<.001	<.001	3	8
OV	C1R →	+0.781	+0.050	<.001	<.001	3	8
OV	CNN2 →	+1.049	+0.062	<.001	<.001	3	8
GBM	RCN3 →	+0.779	+0.051	<.001	<.001	3	7
GBM	C1QA →	+0.660	+0.044	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033273 vs DPYD — GBM

Explore this scatter interactively →