Response to vitamin

Across TCGA patient cohorts, RNA activity of the Response to vitamin pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP1B, SPP1, and JCAD, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to vitamin activity versus MAP1B in LSCC (Pearson r = 0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP1B →	+2.123	+0.682	<.001	<.001	3	9
HNSC	SPP1 →	+2.612	+0.515	<.001	<.001	3	9
OV	JCAD →	+0.918	+0.425	.002	.002	3	8
HNSC	COL1A1 →	+1.297	+0.379	<.001	<.001	3	8
BRCA	CMTM3 →	+0.580	+0.231	<.001	.001	3	8
LUAD	DIRAS1 →	+0.872	+0.328	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033273 vs MAP1B — LSCC

Explore this scatter interactively →