Positive regulation of amine metabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of amine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HPRT1, MAOB, and PHKA1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of amine metabolic process activity versus HPRT1 in OV (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	HPRT1 →	+0.376	+0.065	<.001	<.001	3	7
BRCA	MAOB →	+1.076	+0.116	<.001	<.001	3	5
GBM	PHKA1 →	+0.438	+0.081	<.001	<.001	3	5
BRCA	PAM →	+0.400	+0.068	.002	.008	3	5
BRCA	PNPO →	+0.226	+0.071	.001	<.001	3	4
OV	SYAP1 →	+0.436	+0.089	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033240 vs HPRT1 — OV

Explore this scatter interactively →