Positive regulation of amine metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of amine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NELFB, SPINT1, and LOXL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NELFB grouped by Positive regulation of amine metabolic process-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	NELFB →	-0.836	-1.200	<.001	.007	3	5
BREAST	SPINT1 →	+1.875	+0.775	.001	.002	3	5
LUNG_NSCLC_LUAD	LOXL2 →	-1.741	-0.843	.002	.004	3	4
BLOOD_Leukemia	DENND1C →	+1.681	+1.305	.002	<.001	3	4
BONE	CA13 →	-1.028	-1.546	<.001	.004	3	4
LARGE_INTESTINE	JUP →	+2.611	+1.333	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NELFB by Positive regulation of amine metabolic process activity — PANCREAS

Explore this box plot interactively →