Regulation of amine metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of amine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKAP9, CIB1, and TGM2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AKAP9 grouped by Regulation of amine metabolic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	AKAP9 →	+0.985	+0.333	.003	.004	3	4
CNS	CIB1 →	-0.912	-1.132	.001	.001	3	4
CNS	TGM2 →	-2.723	-0.748	<.001	.006	3	4
URINARY_TRACT	RSRC2 →	+0.522	+1.866	.005	<.001	3	4
BREAST	C17orf80 →	+0.665	+0.618	.003	.009	3	3
LUNG_NSCLC_LUSC	PP2D1 →	+0.082	+0.844	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AKAP9 by Regulation of amine metabolic process activity — LUNG_SCLC

Explore this box plot interactively →