Regulation of amine metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of amine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MARS2, NOB1, and RTN4IP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of amine metabolic process activity versus MARS2 in SKIN (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MARS2 →	+1.132	+0.429	<.001	<.001	3	6
STOMACH	NOB1 →	+1.045	+0.426	.007	.008	3	6
UPPER_AERODIGESTIVE_TRACT	RTN4IP1 →	+0.962	+0.370	<.001	<.001	2	7
BONE	METAP2 →	+0.654	+0.440	.003	.003	3	6
LUNG_NSCLC_LUSC	EEF2K →	+1.022	+0.420	.004	.003	2	6
OESOPHAGUS	MICALL1 →	-1.276	-0.353	.007	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033238 vs MARS2 — SKIN

Explore this scatter interactively →