Negative regulation of protein sumoylation

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein sumoylation pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ETV3, UBAP2L, and JMY, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein sumoylation activity versus ETV3 in DLBC (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	ETV3 →	+1.287	+0.088	<.001	<.001	3	34
DLBC	UBAP2L →	+1.169	+0.091	<.001	<.001	3	34
UVM	JMY →	+1.467	+0.060	<.001	<.001	3	34
DLBC	GARRE1 →	+1.107	+0.084	<.001	<.001	3	34
UVM	ZNF507 →	+1.062	+0.055	<.001	<.001	3	34
TGCT	TTC28 →	+1.048	+0.079	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033234 vs ETV3 — DLBC

Explore this scatter interactively →