Negative regulation of protein sumoylation

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of protein sumoylation pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 11 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher Negative regulation of protein sumoylation pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and UCEC, show the opposite pattern, with higher activity associated with better survival.

MESO, KIRC, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	All	0.268	0.452	<.001	113	view →
KIRC	DFS	Median	III,IV	0.770	0.519	.002	59	view →
KIRP	OS	Quartile	All	0.749	0.959	<.001	54	view →
PAAD	DFS	Median	All	0.172	0.365	.003	48	view →
THCA	OS	Median	II,III,IV	0.532	1.000	<.001	45	view →
UVM	OS	Quartile	III,IV	0.608	1.000	.008	34	view →
UCEC	DFS	Median	IV	0.869	0.510	.001	30	view →
CESC	OS	Median	IV	0.796	0.347	.006	22	view →
GBM	OS	Tertile	All	0.571	0.217	.008	21	view →
ACC	DFS	Tertile	III,IV	0.515	0.077	.003	19	view →
BRCA	OS	Tertile	III,IV	0.626	0.394	.021	19	view →
STAD	DFS	Tertile	All	0.575	0.777	.021	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0033234–MESO (DFS)

Open the MESO breakdown →