Negative regulation of protein sumoylation

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein sumoylation pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TP53BP1, RCN2, and RNF213, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein sumoylation activity versus TP53BP1 in LUAD (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TP53BP1 →	+0.276	+0.051	.002	.002	3	5
LSCC	RCN2 →	+0.376	+0.047	<.001	<.001	3	4
LSCC	RNF213 →	-0.314	-0.044	.001	.001	3	4
LSCC	RPS6KA4_S682 →	-0.526	-0.055	<.001	<.001	3	4
COAD	RO60 →	+0.234	+0.057	<.001	<.001	3	4
UCEC	CHD1L →	+0.245	+0.064	.004	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033234 vs TP53BP1 — LUAD

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