Negative regulation of protein sumoylation

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein sumoylation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS2P2, RNU6-414P, and ATP6V0D1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein sumoylation activity versus RPS2P2 in BRCA (Pearson r = -0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPS2P2 →	+0.123	+0.092	.009	.002	3	4
PDAC	RNU6-414P →	+0.446	+0.180	.004	.008	3	4
HNSC	ATP6V0D1 →	+0.427	+0.210	.002	<.001	3	4
CCRCC	LMO7-AS1 →	+0.294	+0.109	.004	.004	3	4
UCEC	ERO1B →	-0.571	-0.085	.003	.007	3	3
COAD	SYNPR →	+0.391	+0.117	.009	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033234 vs RPS2P2 — BRCA

Explore this scatter interactively →