Negative regulation of protein sumoylation

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein sumoylation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R3D, FOSL1, and CD81, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP1R3D grouped by Negative regulation of protein sumoylation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PPP1R3D →	-0.864	-0.361	.002	<.001	3	5
BREAST	FOSL1 →	+2.169	+0.692	.005	.001	2	5
OVARY	CD81 →	-0.834	-0.557	<.001	.001	3	4
LIVER	NTN4 →	-1.833	-0.290	.001	<.001	3	4
LUNG_NSCLC_LUAD	NOLC1 →	+0.575	+0.530	.002	.002	3	3
URINARY_TRACT	HMGA1 →	+1.465	+0.175	<.001	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP1R3D by Negative regulation of protein sumoylation activity — LIVER

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