Leptin-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Leptin-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMUB2, STAT3, and TMSB15A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leptin-mediated signaling pathway activity versus TMUB2 in BLOOD_Leukemia (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TMUB2 →	+0.366	+0.311	.009	.001	2	5
BREAST	STAT3 →	+1.315	+0.426	.005	.005	3	4
LUNG_SCLC	TMSB15A →	-3.309	-0.345	<.001	<.001	3	3
LUNG_SCLC	PELI3 →	-0.624	-0.209	.004	.001	2	4
LUNG_SCLC	STX1B →	-1.731	-0.257	<.001	<.001	3	3
BLOOD_Leukemia	NUDT1 →	-1.123	-0.564	.009	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033210 vs TMUB2 — BLOOD_Leukemia

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