Tumor necrosis factor-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Tumor necrosis factor-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LPXN, KCTD12, and ANKRD44, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tumor necrosis factor-mediated signaling pathway activity versus LPXN in LSCC (Pearson r = 0.68).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LPXN →	+0.697	+0.066	<.001	<.001	3	8
GBM	KCTD12 →	+0.494	+0.043	<.001	<.001	3	8
LSCC	ANKRD44 →	+0.432	+0.042	<.001	<.001	3	8
GBM	LCP1 →	+0.910	+0.067	<.001	<.001	3	8
GBM	ARHGAP30 →	+0.722	+0.061	<.001	<.001	3	8
LSCC	WIPF1 →	+0.429	+0.049	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033209 vs LPXN — LSCC

Explore this scatter interactively →