Tumor necrosis factor-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Tumor necrosis factor-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRT18, KRT8, and CCNB1IP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tumor necrosis factor-mediated signaling pathway activity versus KRT18 in BRCA (Pearson r = -0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KRT18 →	+1.060	+0.193	<.001	<.001	3	6
BRCA	KRT8 →	+0.946	+0.234	<.001	<.001	3	6
LSCC	CCNB1IP1 →	-0.459	-0.179	.005	<.001	3	6
OV	TRAV19 →	+0.643	+0.186	.008	.001	3	5
HNSC	CPHL1P →	+0.484	+0.132	.006	<.001	3	5
LSCC	TMEM97 →	-1.147	-0.214	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033209 vs KRT18 — BRCA

Explore this scatter interactively →