Tumor necrosis factor-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Tumor necrosis factor-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDB2, BAX, and TRAF3IP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DDB2 grouped by Tumor necrosis factor-mediated signaling pathway-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DDB2 →	-2.052	-1.888	.004	<.001	3	6
STOMACH	BAX →	-1.210	-1.280	.005	.008	3	5
LARGE_INTESTINE	TRAF3IP2 →	-1.008	-0.861	.004	.009	3	4
LUNG_SCLC	SHROOM2 →	-1.912	-1.090	.006	.008	3	4
KIDNEY	MDM2 →	-1.369	-1.268	.004	.001	3	4
KIDNEY	MECP2 →	+0.566	+0.982	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DDB2 by Tumor necrosis factor-mediated signaling pathway activity — URINARY_TRACT

Explore this box plot interactively →