Tumor necrosis factor-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Tumor necrosis factor-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1QBP, LGALS1, and COX10, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tumor necrosis factor-mediated signaling pathway activity versus C1QBP in SOFT_TISSUE (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	C1QBP →	+1.283	+0.483	<.001	.007	3	6
OVARY	LGALS1 →	+2.566	+0.360	.001	.009	3	5
LUNG_SCLC	COX10 →	+0.695	+0.308	.004	.004	3	5
LARGE_INTESTINE	RHOD →	-1.870	-0.451	.002	.001	3	5
LARGE_INTESTINE	SAA1 →	-2.573	-0.468	<.001	.001	3	5
URINARY_TRACT	IFT57 →	+0.779	+1.293	.009	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033209 vs C1QBP — SOFT_TISSUE

Explore this scatter interactively →