Response to vitamin E

Across TCGA patient cohorts, RNA activity of the Response to vitamin E pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGF1R, AHSA2P, and TM2D3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to vitamin E activity versus IGF1R in OV (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IGF1R →	+1.334	+0.315	<.001	.001	3	4
LSCC	AHSA2P →	+0.294	+0.114	.009	.002	3	4
LSCC	TM2D3 →	+0.241	+0.107	.003	.006	3	4
COAD	SNRPN →	+0.504	+0.534	<.001	<.001	3	4
LSCC	SCHIP1 →	+0.646	+0.161	<.001	.001	3	4
OV	ZNF280D →	+0.364	+0.318	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033197 vs IGF1R — OV

Explore this scatter interactively →