Regulation of intracellular protein transport

Across TCGA cell cohorts, RNA activity of the Regulation of intracellular protein transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM222B, SEMA7A, and PDE9A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM222B grouped by Regulation of intracellular protein transport-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	FAM222B →	+1.380	+0.245	.002	.005	3	4
LUNG_NSCLC_LUSC	SEMA7A →	-3.981	-0.203	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	PDE9A →	+1.447	+0.110	.003	.004	3	4
LUNG_SCLC	KCNC1 →	+1.636	+0.237	.005	.001	3	4
LUNG_SCLC	ZNF286A →	+0.919	+0.171	.006	.001	3	4
LUNG_SCLC	FGD3 →	+2.954	+0.260	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM222B by Regulation of intracellular protein transport activity — BLOOD_Lymphoma

Explore this box plot interactively →