V(D)J recombination

Across TCGA patient cohorts, RNA activity of the V(D)J recombination pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SAMHD1_T592, SEPTIN1_S206, and STAT2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, V(D)J recombination activity versus SAMHD1_T592 in CCRCC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SAMHD1_T592 →	+0.536	+0.036	<.001	<.001	3	5
LSCC	SEPTIN1_S206 →	+0.588	+0.043	.003	.003	3	5
LUAD	STAT2 →	+0.242	+0.050	.001	.001	3	5
CCRCC	FGD3_S547 →	+0.461	+0.041	<.001	<.001	3	5
CCRCC	MXRA5 →	+0.761	+0.038	.002	.001	3	5
LSCC	SPINT1 →	-0.331	-0.035	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033151 vs SAMHD1_T592 — CCRCC

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