V(D)J recombination

Across TCGA pan-cancer cohorts, RNA activity of the V(D)J recombination pathway is associated with patient survival in 28 of 34 cancer lineages. Pathway activity is summarized from the expression of its 19 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher V(D)J recombination pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and LUAD, show the opposite pattern, with higher activity associated with better survival.

KIRP, HNSC, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.498	0.771	<.001	115	view →
HNSC	OS	Median	All	0.766	0.612	<.001	111	view →
KIRC	DFS	Quartile	All	0.705	0.841	<.001	98	view →
LIHC	DFS	Quartile	All	0.399	0.639	<.001	81	view →
ACC	DFS	Median	All	0.172	0.576	<.001	74	view →
THCA	DFS	Tertile	III,IV	0.448	0.901	<.001	45	view →
UVM	DFS	Tertile	All	0.315	0.801	.004	45	view →
LUAD	DFS	Tertile	All	0.733	0.607	.007	41	view →
LGG	DFS	Median	All	0.671	0.789	<.001	39	view →
UCS	OS	Median	II,III,IV	0.679	0.241	.002	38	view →
COAD	OS	Median	All	0.811	0.921	.002	31	view →
MESO	DFS	Tertile	All	0.244	0.387	.013	27	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

GO:0033151–KIRP (OS)

Open the KIRP breakdown →