V(D)J recombination

Across TCGA cell cohorts, RNA activity of the V(D)J recombination pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFT52, HTD2, and GADD45A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IFT52 grouped by V(D)J recombination-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	IFT52 →	-0.850	-0.268	<.001	.001	3	5
LUNG_NSCLC_LUAD	HTD2 →	-0.512	-0.172	.002	.001	3	5
BLOOD_Leukemia	GADD45A →	-1.508	-0.181	.002	.001	3	4
LUNG_SCLC	DLX1 →	-2.010	-0.322	.009	<.001	3	4
LIVER	SDF2L1 →	+0.858	+0.219	.004	.005	3	4
STOMACH	SMPDL3B →	+2.431	+0.186	.008	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IFT52 by V(D)J recombination activity — LUNG_SCLC

Explore this box plot interactively →