V(D)J recombination

Across TCGA cell cohorts, RNA activity of the V(D)J recombination pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMC2, STOML1, and DYNC2I1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SMC2 grouped by V(D)J recombination-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SMC2 →	-0.370	-0.074	.002	.009	1	7
STOMACH	STOML1 →	+0.220	+0.114	.001	.002	3	4
LUNG_NSCLC_LUAD	DYNC2I1 →	+0.155	+0.070	.004	.001	3	4
LUNG_NSCLC_LUAD	RBM14 →	-0.260	-0.089	<.001	<.001	3	4
KIDNEY	STX1A →	+0.284	+0.057	.002	.003	3	4
KIDNEY	FMO1 →	-0.176	-0.059	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SMC2 by V(D)J recombination activity — OVARY

Explore this box plot interactively →