Regulation of intracellular steroid hormone receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of intracellular steroid hormone receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMA7, PMM1, and DPM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of intracellular steroid hormone receptor signaling pathway activity versus PSMA7 in LUNG_NSCLC_LUSC (Pearson r = -0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PSMA7 →	-0.828	-0.181	.004	<.001	3	5
URINARY_TRACT	PMM1 →	-1.219	-0.335	.001	<.001	3	5
BREAST	DPM1 →	-0.692	-0.149	.007	.001	3	5
LARGE_INTESTINE	PCED1B →	+1.076	+0.149	.001	.004	3	5
LUNG_NSCLC_LUSC	NXPE3 →	+2.174	+0.194	.002	.007	2	5
LUNG_NSCLC_LUSC	ZNF233 →	+0.809	+0.205	.005	.007	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033143 vs PSMA7 — LUNG_NSCLC_LUSC

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